Download Eplerenone Mechanism Of Action Images. Few studies have comparatively evaluated whether eplerenone as well as spironolactone display cardioprotective effects independent of the blockade of aldosterone. Eplerenone reduced the risk of death and hospitalization in patients with mild heart failure in the emphasis trial, dr.
Spironolactone (and its active metabolite canrenone) and eplerenone.
Eplerenone is a medication used in the management and treatment of heart failure with reduced ejection fraction, as well as hypertension. We also review the current status in understanding the molecular mechanisms of action of the mr and its ligand. Spironolactone (and its active metabolite canrenone) and eplerenone. Aldosterone synthesis, which occurs primarily in the adrenal gland, is modulated by multiple factors.